Translation of mouse model to human gives insights into periodontitis etiology.

Six DEGs (PARP1, DUSP23, PCDH17, PSEN2, H3f3aos, EPHX1 ) located to the QTLs Perio 3 and Perio4 ( Table 1 , H3f3oas and Dusp 23 have no human orthologous and showed only borderline significance with P = 0.07). 15 DEGs had been reported in previous human GWAS on periodontitis with P < 9 × 10 −6 ( C1orf 87, HLA-DOA, BIRC 5 , CCDC 13 , GLDC, GPR 141 , OTOF, IFI 16 , ETNK 2 , TTLL 11 , ATP 5 S, GRID 1 , LBP, NIN , and VAV 1; Appendix Table 4 ) .

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