The results suggest that considering time to infection in the protection from parasitaemia assay as a measure of protective activity may be helpful in discriminating differences in potency; however, larger group sizes are needed given the highly significant discrimination of functional activity seen in the pooled result (Table 7 ).
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Characterization of two in vivo challenge models to measure functional activity of monoclonal antibodies to Plasmodium falciparum circumsporozoite protein.
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