highly significantp < 0.001
In contrast, at 42 days, a significant difference was determined between the Lp- pSIP-409-16- and the Lp- pSIP-409-17-immunized groups ( p < 0.05), and a highly significant difference ( p < 0.001) was recorded between the Lp- pSIP-409-17- and both of the Lp- pSIP-409-pgsA- and the saline-immunized groups.