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The important effect of 5-HTTLPR polymorphism on the risk of depression in patients with coronary heart disease: a meta-analysis.

BMC Cardiovasc Disord · 2020 · PMC7081537 · PMID 32188408

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an increasing trendno p-value reported
Background Depression has taken a pivotal place in contributing to coronary heart disease (CHD), what’s worse, the comorbidity accounts for an increasing trend of mortality [ 1 – 4 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.