highly significantp < 0.0001
Conversely, we observed in the Ptch1 +/− /Btg1 KO MBs a highly significant increase in the percentage of caspase-3-positive cells to the total number of cells (apoptotic index), with respect to the Ptch1 +/− /Btg1 WT tumors ( p < 0.0001 and 42% increase; Mann–Whitney U -test; Figures 1C,D ).