a trend towards significancep = 0.095
In the very low, low, high, and very high Quartiles, 26% (67 of 262), 18% (46 of 250), 16% (38 of 232), and 20% (45 of 223) of participants, respectively, had at least one severe respiratory exacerbation, with a trend towards significance (Cochran-Armitage p = 0.095).