Identifying the drivers of computationally detected correlated evolution among sites under antibiotic selection.

Notably, all highly significant pairs of substitutions were synonymous and hence, unlikely to affect drug resistance or fitness (but see Agashe et al., 2016 ; Bailey, Hinz, & Kassen, 2014 ; Plotkin & Kudla, 2011 ), save for one pair of nonsynonymous sites, gyrA (c248t)‐ parC (c260g/t), that presumably impacts the level of resistance (Figure 1 ).

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