Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription.

Consistent with this, a phosphoproteomic analysis showed that the changes in phosphorylation induced by siRNA-mediated depletion of NUAK1 in U2OS cells showed a statistically highly significant overlap with changes induced by BAY-880 ( Figure 4 D; p = 1.5 × 10 −13 ), and a GO term analysis of changes of differentially regulated phosphosites showed that processes targeted by BAY-880 highly overlapped with the ones targeted by depletion of NUAK1 ( Figure 4 D).

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