Indeed, analysis of the upper quartile cross-sectional tubular area and cell count at E17.5, P1 and P7 in Vangl2 Δ/CD vs control kidneys revealed a highly significant difference during the embryonic phase, which was reduced yet still significant at P1 and completely disappeared by P7 ( Fig 5C and 5D ).
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Differential role of planar cell polarity gene Vangl2 in embryonic and adult mammalian kidneys.
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