Organotypic culture as a research and preclinical model to study uterine leiomyomas.

At transcription level, we observed that Cyclin D1 (CCND1) whose activity is required for cell cycle G1/S transition, was significantly upregulated by E2 (p = 0.04) and close to significance by P4 (p = 0.06) and E2 + P4 (0.06) at 24 h and its transcript levels seem to remain upregulated at 48 h and 72 h (Fig. 3 ).

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