The Na,K-ATPase acts upstream of phosphoinositide PI(4,5)P₂ facilitating unconventional secretion of Fibroblast Growth Factor 2.

While α1-subCD3 variants with substitutions of K524 and E525 did not show a phenotype under these conditions, the D560N substitution in α1-subCD3 resulted in a highly significant decrease of the interaction with FGF2 ( p value = 0.008) (Fig. 7b ).

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