Host-directed therapies for bacterial and viral infections.

Nat Rev Drug Discov · 2018 · PMC7097079 · PMID 28935918

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highly significantno p-value reported

In this regard, a recent reanalysis of de-identified data from a phase II trial of the IL-1 receptor antagonist anakinra in severe sepsis revealed a highly significant improvement in 28-day survival in a subset of patients who had concurrent hepatobiliary dysfunction and disseminated intravascular coagulation (DIC) 237 .

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