Interferons at age 50: past, current and future impact on biomedicine.

Nat Rev Drug Discov · 2007 · PMC7097588 · PMID 18049472

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may be significantno p-value reported

Fatigue and anorexia, the aetiology of which is not understood, are often dose-limiting with chronic administration for cancer or MS; at higher doses weight loss occurs and may be significant (>10%).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.