Investigators have reported an elevated CXCR4 resistance to cytarabine when AML cells were grown with homing bone marrow stromal cell (hBMSC), proposing that other BMSC secreted factor(s) might not be significant in their culture system.
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Significance of CXCL12/CXCR4 Ligand/Receptor Axis in Various Aspects of Acute Myeloid Leukemia.
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