Genetic Characterization and Risk Stratification of Acute Myeloid Leukemia.

This kind of cytogenetic aberration is highly significant for diagnosis and therapy management, since on its own associates with favorable outcomes, high remission rates and long median survival, whereas c-Kit mutations occurring concurrently with t(8;21)(q22; q22) , compose an independent adverse prognostic biomarker ( Table 2 , Figure 2 ).

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