Gene-expression analysis of microdissected neurons revealed an interesting trend in the expression of IL-6 ( interleukin-6 ): While neuronal IL-6 was largely undetectable or detected at extremely low levels in most animals, four Tg rats exhibited very high expression levels compared with the control group.
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Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain.
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