Constitutionally High Serotonin Tone Favors Obesity: Study on Rat Sublines With Altered Serotonin Homeostasis.

Differences between 5HT sublines, when existed, were small in amount and not quite significant, but by summing up the overall effect, it seems that in high-5HT animals orexigenic signaling peptides are, or tended to be, upregulated in comparison to low-5HT animals (H/L: Npy = 1.05; Npyr = 1.14, Agrp = 1.29; Hcrt = 1.06; Hcrtr = 1.17; Mch = 1.09; Figure 3A ), whereas anorexigenic peptides show tendency in the opposite direction [H/L: Pomc = 0.94: Bdnf = 0.97 ( Figure 3 ) and also ApoA4 = 0.54; Crh = 0.90 ( Table 1 )].

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