Microglia have a protective role in viral encephalitis-induced seizure development and hippocampal damage.

Survival analysis resulted in a highly significant difference between infected B6 vehicle controls and PLX5622-treated mice ( Fig. 10 D). 3.9 CSF1R inhibition facilitates seizure induction in the TMEV model When determining the daily incidence of seizures across the 7 days after infection, maximum seizure occurrence was reached significantly more rapidly in PLX5622-treated mice than in vehicle controls, indicating that microglia depletion facilitated seizure induction ( Fig. 11 A).

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