SLE pathogenesis is very complex, subject to both environmental factors – like viruses 66 , bacteria 67 , but also to drugs 68 (and this is highly significant) – and also to genetic susceptibility (for example HLA polymorphism) 69 , 70 as well as hormonal factors (in fact, it has a considerable prevalence in the female gender) 71 .
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Causality assessment of adverse events following immunization: the problem of multifactorial pathology.
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