Short- and long-term efficacy of prednisolone for first acute rhinovirus-induced wheezing episode.

Moreover, systemic corticosteroids, when combined with nebulized epinephrine, were of borderline significance in reducing the need for hospitalization in infants with bronchiolitis, and the effect was not affected by positive RSV status (rhinovirus was not examined), a personal or family history of atopy, presentation early in the course of illness, or severe illness. 31 Four studies have not shown an effect in children with atopic characteristics, but they have been underpowered to fully address the atopy issue, or the prednisolone was parent initiated. 15 , 17 , 31 , 33 When looking at longer-term outcomes (ie, ≥2 months), prednisolone made a difference only for those with high rhinovirus loads.

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