Barely Significant
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Analysis of mRNA expression for genes associated with regulatory T lymphocytes (CD25, FoxP3, CTLA4, and IDO) after experimental infection with bovine viral diarrhea virus of low or high virulence in beef calves.

Comp Immunol Microbiol Infect Dis · 2014 · PMC7112516 · PMID 25456194

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highly significantno p-value reported
In contrast, LV BVDV infection with SD-1 did yield a highly significant increase in IDO mRNA level.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.