A highly significant elevation of ID1 was observed in CD33 + CD11b + CD14 + HLA-DR low monocytic MDSC in the blood of melanoma patients compared to their HLA-DR high counterparts, while expression of ID1 correlated positively with established MDSC markers S100A8/9 and iNOS.
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High expression of ID1 in monocytes is strongly associated with phenotypic and functional MDSC markers in advanced melanoma.
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With near significance, a trend towards an increase was seen for IRF8 after surgery (Fig. 3 ).