14 Another extremely significant issue related to depression is the deleterious impact it causes on the quality of life (QoL) of HD patients, which is even more relevant when it occurs in a population that often presents multiple comorbidities and a stressful routine involving high levels of physical and mental stress. 15 Studies with larger sample sizes and greater methodological rigor, in which depression is diagnosed through the gold standard (standardized psychiatric interview), are lacking.
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