Immunotherapy against experimental canine visceral leishmaniasis with the saponin enriched-Leishmune vaccine.

While an increase in the number of symptoms was noted in both the vaccinees and untreated controls throughout the experiment, the differences in number of clinical signs were highly significant, both between treatments (ANOVA, p < 0.0001) and between times (ANOVA, p < 0.0001).

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On the other hand, the IgG1 antibodies diminished after vaccination and showed a mild trend to increase in the untreated infected animals (TH2 immune response) ( Fig. 1 C).

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