Oncogenic Kras^G12D causes myeloproliferation via NLRP3 inflammasome activation.

Within the Kras G12D BM, the Nlrp3 gene was highly significant upregulated (Fig. 1a, red arrow ), and a selective clustering of the gene set inflammasome from Reactome showed upregulation of multiple NLRP3 inflammasome related genes (Fig. 1b ).

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