Innate immune activation as a broad-spectrum biodefense strategy: prospects and research challenges.

Microarray analyses reveal numerous and highly significant changes in gene transcription in cells of the innate immune system after exposure to pathogens, 2 but at the same time, mutations in single genes of innate immune receptors might greatly increase the risk of infection or sepsis. 3 , 4 The needs of biodefense to protect against a broad and largely

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