Safety of antimicrobial de-escalation for culture-negative severe pneumonia.

s pmc-prop-pdf-only no pmc-prop-suppress-copyright no pmc-prop-is-real-version no pmc-prop-is-scanned-article no pmc-prop-preprint no pmc-prop-in-epmc yes 1 Introduction Although the incidence and mortality of sepsis and septic shock vary across regions, the incidence of these conditions is showing an increasing trend and poses a major public health burden worldwide [ [1] , [2] , [3] , [4] , [5] ].

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