Genetic associations of fatigue and other symptom domains of the acute sickness response to infection.

Regression modelling to predict extreme scores in the fatigue domain produced a highly significant solution [ χ 2 (5) = 30.1; p < 0.001] which indicated that the putative high cytokine producing T allele of the IFN-γ +874 T/A SNP was the best predictor of severe fatigue [ p < 0.001; OR: 3.6 (95% confidence interval (CI): 1.8–7.2].

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The best solution for extreme scores in the pain symptom domain [ χ 2 (5) = 21.6; p = 0.001] identified RRV infection as the best and only predictor for high pain severity [ p = 0.004; OR: 3.5 (95% CI: 1.5–8.1]; this model also included the IL-6 SNP, however the association with the high producing G allele failed to reach significance ( p = 0.08).

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