Complementary to these findings, double staining of muscle sections with GFP and pSMAD3 revealed a positive trend toward increased number of pSMAD3 + cells in the GFP population (Fig 5 B middle and right panels and E), suggesting a tendency to increased TGFβ signaling also in mdx Cripto KO MPs.
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Cripto shapes macrophage plasticity and restricts EndMT in injured and diseased skeletal muscle.
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