A six-gene leukemic stem cell score identifies high risk pediatric acute myeloid leukemia.

Each unit increase in pLSC6 had a marginally significant association with worse OS in the GO arm of AAML0531 (HR = 1.64, 95% CI: 0.96, 2.79; p = 0.069) and the AAML03P1 protocol (HR = 2.3, 95% CI: 0.99, 5.38; p = 0.053). pLSC6 may identify the best candidates for transplant Among standard and high-risk patients of both the AML02 and TARGET cohorts, transplant was associated with better outcomes compared to chemotherapy alone for patients with low-pLSC6 score, but transplant and chemotherapy alone showed similarly dismal outcomes for patients with high-pLSC6 score ( Figure 6A – D ).

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