MDM2 Inhibition in a Subset of Sarcoma Cell Lines Increases Susceptibility to Radiation Therapy by Inducing Senescence in the Polyploid Cells.

The colony-forming abilities of the 2N population were higher compared with the 4N population in all treatment groups (5 μM nutlin-3 alone, 5 μM nutlin-3 plus RT for LPS853 and T778; P value ≤.05) with a nonsignificant trend in the RT alone group (LPS853; P = .44, T778; P = .08).

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