Vitamin E and Mortality in Male Smokers of the ATBC Study: Implications for Nutritional Recommendations.

In 1971, Pauling published a meta-analysis in which he showed that there was highly significant evidence from four placebo-controlled trials that vitamin C is beneficial against the common cold with p = 0.00002 ( 56 ), a conclusion that has since been corroborated in a large series of further randomized trials ( 57 , 58 ).

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