ECM Characterization Reveals a Massive Activation of Acute Phase Response during FSGS.

Furthermore, the fibrinogen α-, β-, and γ-chains (FGA, FGB, FGG) were strongly upregulated during FSGS, although FGA failed to reach significance ( Table 1 , Table S1 , Figure 2 a,b). α-globin (HBA1), β1-globin (HBBB1), and β2-globin (HBB-B2) were strongly enhanced, while the polymeric immunoglobulin receptor (PIGR) and the pulmonary surfactant-associated protein D (SFTPD) were even exclusively detected in the FSGS samples.

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