Although the number of genes in prognostic signatures had a decreasing trend as a whole [ 50 , 51 ], most of the previous prognostic signatures were often in the form of a union set of dozens or hundreds of genes, or even a network module [ 6 , 52 , 53 , 54 ].
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Network Properties of Cancer Prognostic Gene Signatures in the Human Protein Interactome.
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