Machine learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes.

Nucleic Acids Res · 2020 · PMC7144921 · PMID 32095818

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highly significantno p-value reported

Despite highly significant improvement in the AUC values, from previously 0.94 ( 22 ) to now 0.9964, the sobering truth is, that in the present state, the signal quality does not allow meaningful mapping of eukaryotic transcriptomes, which contain in the order of 10 7 adenosines.

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