Intertwined Functions of Separase and Caspase in Cell Division and Programmed Cell Death.

We found that the sep-1(ts) mutant grown at permissive temperature showed a highly significant reduction in the number of apoptotic corpses (average of 2.4 ± 1.2 corpses; n = 53; p = 6.4 × 10 −15 ) at the “comma” stage of embryogenesis compared to that in wild type (N2) embryos (average of 4.4 ± 1.2; n = 121; Fig. 1B ).

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