Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors.

37 , 38 These proteins may therefore represent novel biomolecular interactions for phthalazinone-based PARP inhibitors, 33 , 34 and engagement of these targets may be significant for the polypharmacology of phthalazinone-based PARP inhibitors in the clinic, leading to deeper understanding of toxicology or novel indications.

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