highly significantp < 0.01
All parameters in the statistical model were highly significant: compound ( F 26,347 = 3.84, p < 0.01), dose ( F 1,347 = 309.75, p < 0.01), the compound by dose interaction ( F 26,347 = 2.27, p < 0.01), and time ( F 2,347 = 41.27, p < 0.01).