borderline significantp = 0.053
Mutation profiles of 578 cancer-relevant genes Numbers of mutations Somatic mutational analysis identified an average of 174 non-synonymous somatic mutations per Mb in dMMR LS-BCs, compared with 33/Mb in pMMR LS-BCs (non-significant difference) and 88/Mb in NC-BCs (borderline significant relative to dMMR LS-BC, p = 0.053) ( Table 2 ).