Inhibition of SYK kinase does not confer a pro-proliferative or pro-invasive phenotype in breast epithelium or breast cancer cells.

In agreement with our findings, the very recent landmark analysis of somatic mutations detected in 560 human breast cancers did not find any mutations in the SYK gene [ 37 ], compared to highly significant mutation rates for the known proto-oncogenes TP53 and PTEN.

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