23–25 An earlier study on similarly sized ulcers in around 36 patients found a highly significant improvement in the healing rate (sq. mm/day) in patients with prolonged acidification of the ulcer as compared with controls. 26 In fact, Manuka honey dressings are used in chronic wound treatments due to its ability to maintain an acidic environment. 27 Nonhealing chronic wounds that had no reduction in wound size over the 3 weeks preceding treatment, exhibited a significant reduction (almost 30%) in wound size when treated with these dressings in just 2 weeks. 14 These results support that wound alkalinity may be used as an indicator for the prognosis of wound healing status.
1
—
—