Intriguingly, there was a highly significant increase in serum VEGF‐A protein levels in Spint1 LoxP/LoxP /Villin‐Cre / Apc Min/+ mice that was abolished with compound deficiency of PAR‐2 (Figure 4 A).
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Protease-activated receptor-2 accelerates intestinal tumor formation through activation of nuclear factor-κB signaling and tumor angiogenesis in Apc<sup>Min/+</sup> mice.
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