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Clinical outcomes of empirical high-dose meropenem in critically ill patients with sepsis and septic shock: a randomized controlled trial.

J Intensive Care · 2020 · PMC7158081 · PMID 32318268

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an increasing trendno p-value reported
Consequently, an increasing meropenem plasma concentration in the high-dose group might assumingly have an increasing trend in meropenem concentration in ELF, which was a target site in almost half of the patients in our study.

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