highly significantP < 0.001
In models that used both Amyloid PET and P-tau217 or P-tau181 as predictors, the effect of Amyloid PET on Tau PET showed a full mediation, as the effect of Amyloid PET on Tau PET was reduced from highly significant ( P < 0.001) to nonsignificant ( P = 0.12 to 0.25).