In a systematic review of 25 studies, the adjusted RR for stroke ranged between 1.1 and 1.6, with apparently an increasing trend by increasing grade or airflow limitation. 55 However, in the systematic review of Chen et al, the current evidence on stroke risk among COPD patients was limited by a dependence on cross-sectional data, which precluded a firm establishment of causality between COPD and stroke. 6 Systematic Reviews
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Insights into Chronic Obstructive Pulmonary Disease as Critical Risk Factor for Cardiovascular Disease.
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