Barely Significant
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ASA Suppresses PGE<sub>2</sub> in Plasma and Melanocytic Nevi of Human Subjects at Increased Risk for Melanoma.

Pharmaceuticals (Basel) · 2020 · PMC7168893 · PMID 31906519

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highly significantp < 0.0001actually significant
In the 325 mg cohort, plasma salicylate (1061–6299 ng/mL) and salicylurate (673–3355 ng/mL) were detected in 21/21 (100%) subjects ( Figure 4 B), gentisic acid (39–283 ng/mL) was detected in 20/21 (95%) subjects, and salicyl acyl glucuronide (31–396 ng/mL) was detected in 21/21 (100%) subjects ( Figure 4 C) following ASA exposure and were highly significant ( p < 0.0001 for each metabolite, paired t -tests).

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