Inter-α-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation.

The discovery that the vWFA of HC1 shares high structural similarity with vWFA domains of TEM8 and CMG2 may be significant given that these proteins are known to be functional receptors for the anthrax toxin ( 37 ), especially because IαI has been shown to protect against anthrax intoxication ( 54 , 55 ).

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