Arctigenin prevents the progression of osteoarthritis by targeting PI3K/Akt/NF-κB axis: In vitro and in vivo studies.

19 Type II collagen and aggrecan are the major structural constituents of the ECM, 12 , 20 while MMP13, as a vital part of collagenase family, occupies an extremely significant position aiming type II collagen disintegration, and ADAMTS5, as a key member of secreted zinc proteases, shows dramatically destructive effects of aggrecan synthesis. 21 , 22 Moreover, a specific molecular repressor in the NF‐κB p65 nuclear translocation has been verified to delay the process of O

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