Health and economic outcomes of treatment with extended-release naltrexone among pre-release prisoners with opioid use disorder (HOPPER): protocol for an evaluation of two randomized effectiveness trials.

Limitations The generalizability of our findings may be limited to justice-involved persons with an opioid use disorder; however, we believe this study is highly significant due to (a) the size of the US criminal justice population, (b) the rate of drug use disorders among this population, and (c) the concomitant personal and public health costs.

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