Inhibition of GPR91 Reduces Inflammatory Mediators Involved in Active Labor in Myometrium.

Thus, to determine the mechanisms responsible for this increase in GPR91 during labor, we incubated myometrial cells with IL1B and TNF and found a robust and highly significant upregulation of GPR91 mRNA expression at 5 h post treatment, which persisted at 24 h post treatment.

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